Bridging with Clomid

“Clomid” or Clomiphene is a popular selective estrogen receptor modulator, or “SERM”.  It is usually used in post cycle therapy (PCT) to help restore natural hormonal levels after a cycle of prohormones or anabolic steroids.  Now the use of clomid for hormone replacement therapy is nothing particularly new.  In fact, I’ve often suggested it as a way to “bridge” between cycles and possibly a healthier way to ensure consistent recovery of health as opposed to blasting and cruising anabolics.  Bridging with clomid not only makes sense theoretically but there is science to support it’s use as I will explain in this article.

From a scientific perspective a huge 2011 case study gave young men (average age 29) with low testosterone levels clomid for an average of 19 months [1].  It proved that continued clomid administration can maintain testosterone levels within normal range with minimal (if any) side effects.  They gave the men varying doses but all were between 25 to 50 mg’s every other day.  You can see the before and after results in various hormonal markers in this chart:

clomid for trt

One thing you might notice from the chart above is an increase in estradiol or “bad estrogen”.  This is a common occurance with the administration of any SERM, simply because a SERM blocks the action of estrogen at the hypothalamus.  The body responds by increasing circulating estrogen.  This isn’t inherently bad, in fact if you read Boston Lloyd is Taking 2.5 mg’s of Letro Every Day you can learn about a new paper that showed men with higher estrogen levels (and testosterone levels) had a better libido than men with just high testosterone levels.

The one problem with higher estrogen levels is a believed reduction in bone density.  This is the same reason why women are more susceptible to osteoporosis (higher lifetime estrogen levels).  But in men it seems to work a bit differently.  Again a large case study in 2011 gave older men clomid (same dose as previous study) for 3 plus years and measured bone density [2].  They found that clomid had no negative effect on bone density, and if anything it was improved.

How do men feel on Clomid vs. Testosterone

So here’s the big question.  Do men feel as good when taking clomid vs. testosterone?  It’s great that it works on paper, and blood work shows improvements.  But if a man still feels like they have a low libido, energy, and motivation is it still a viable hormone replacement option?

Thankfully this week a study from the Baylor College of Medicine answered just this question [3].  They conducted an analysis of 1,150 men on some form of hormone replacement therapy.  They wanted to control as much as possible so they took a sample of 93 men that were age matched (40 years old).  They also had a control group:

  1. 31 men on nothing (normal men)
  2. 31 men on clomiphene citrate (25 mg’s per day)
  3. 31 men on testosterone gels (Testim 1% or Androgel 1.62%, 2-4 pumps/day)
  4. 31 men on testosterone injections (test cypionate 100 to 200 mg’s per week)

They measured three things:

  • Total testosterone levels
  • Estradiol levels
  • qADAM Score

The qADAM score is a test given to each man to measure subjective characteristics associated with low testosterone.  Each question has a 5 point likert scale.  Higher scores indicate they feel better, and lower scores indicate low testosterone levels.  In other words, this answers how well clomid actually makes men feel better.  Here’s the full qADAM questionnaire if you would like to try it out:

1.         Do you have a decrease in libido (sex drive)?
2.        Do you have a lack of energy?
3.        Do you have a decrease in strength and/or endurance?
4.        Have you lost height?
5.        Have you noticed a decreased “enjoyment of life”?
6.        Are you sad and/or grumpy?
7.        Are you erections less strong?
8.        Have you noted a recent deterioration in your ability to play sports?
9.        Are you falling asleep after dinner?
10.     Has there been a recent deterioration in your work performance?

Did Clomid work as well as Testosterone?

qADAMTheir findings may not be all that surprising.  The average testosterone levels for clomid were 525 ng/dL, testosterone gels averaged 412 ng/dL, and the men on testosterone cypionate injections averaged 1014 ng/dL, or about double that of clomid treatment.  Estradiol levels corresponded to testosterone levels for each group.

Seeing this you would expect the qADAM score to be higher for testosterone injections, right?  Not really.  In fact all four groups had relatively similar qADAM scores ranging from 34 to 39 on a scale of 10 to 50.  The only difference was that men on testosterone injections had a slightly higher score for question #1 (a higher libido).

Practical Application – Bridging with Clomid

In terms of guys who are training hard, eating right, and looking to maintain their gains from cycle to cycle bridging with clomid seems to be a viable alternative.  It’s not going to be as easy to keep gains on something like testosterone injections simply because you’re dealing with half the testosterone levels.  But clomid has other benefits, including maintaining and increasing fertility which might be important if you hope to have children in your future.  It’s also cheap and easy to find (visit Transformix Peptides to find your research SERMS).  And finally various health biomarkers tend to increase faster when you actually cycle anabolics, and clomid gives you this opportunity.

By Travis DeGraff


 

2 thoughts on “Bridging with Clomid – New Research Shows it Works

  1. Trex says:

    I don’t see the results of the question of how people felt on test v. clomid?

    Also, do you think it is possible to get shut down from running clomid for long periods of time (as TRT).

    • Degraff says:

      The results were essentially the same. They measured results by the qADAM score which was the same for almost all the questions except question #1.

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