Ostarine On Cycle – Is it a good idea?

This is a typical question I hear often…

Anabolic Bro: Do you think stacking this [insert any prohormone or traditional anabolic] with Ostarine on cycle will improve my results?  It’s a SARM.

Me: Do you know what the acronym “SARM” even means?

Anabolic Bro: It’s an acronym? Well the guys told me it’s the hot new anabolic option. Lots of people are saying Ostarine on cycle is great and that’s a SARM. So obviously other guys are using on cycle SARMs.  It’s like the opposite of a SERM bro.

Me:  SARM stands for selective androgen receptor modulator.  The purpose of a SARM is to promote anabolic growth in skeletal muscle and bone.  They were originally designed to help elderly people and cancer patients avoid sarcopenia.

Anabolic Bro:  That’s cool, I want muscle growth.

Me:  Yes, in general that’s why we use anabolics and prohormones.  BUT traditional anabolics and prohormones are NOT selective.  Meaning they are anabolic in other organs such as liver, prostate, heart, etc.  So stacking Ostarine with other anabolics simply defeats the purpose of a SARMs selective action.  Using Ostarine on cycle with other anabolics simply makes it an expensive stacker (because let’s face it Ostarine isn’t cheap).

Anabolic Bro:  So it’s cool to use in Post Cycle Therapy (PCT)?

ostarine on cycle

Ostarine’s effect on various hormones

Me:  Well not really.  I say this because we don’t know if Ostarine is suppressive to your natural testosterone when you are using more than 3 mg’s per day.  3 mg’s per day is the most that has ever been studied in people.  And in older men using 3 mg’s per day for 86 days natural free testosterone dropped 23%, and total testosterone dropped 43% [1].  Bodybuilders are using Ostarine in doses 7 to 10 times more than what has been studied in humans (21-30mg’s/day).  Assuming a linear relationship in the dose response of natural testosterone you can assume Ostarine is very suppressive.  Of course most people don’t use it for 12 weeks straight, but it simply means we don’t truly know how suppressive it is in healthy young guys.

Anecdotally guys are reporting that Ostarine is suppressing their natural testosterone levels.  For example a male aged 35 ran Ostarine started taking 5 mg’s/day of Ostarine working up to 10 mg’s [2].  He had blood work done before and 7 days into his ostarine cycle.  His testosterone levels dropped from 15.9 nmol/L to 9.6 nmol/L, or a 40% drop in just 7 days.  There are other anecdotal reports of natural testsoterone suppression from Ostarine as well [3]  This means Ostarine is likely suppressive to your natural testosterone levels, and not something you should use during PCT.

Also worth noting, is Ostarine’s effect on estrogen.  In the same study referenced earlier on elderly men using 3 mg’s per day the found a 37% drop in estradiol.   What is interesting is that many guys have reported increased estrogen levels while using Ostarine, this is believed to be a result of increased expression of the aromatase enzyme (the enzyme that converts testosterone to estrogens).

Anabolic Bro:  Wut?  Cliffs?

Me:  Don’t use Ostarine on cycle unless you want a really expensive anabolic.  Don’t use Ostarine in PCT unless you do not want to fully recover your natural testosterone levels.  Ostarine is probably best used as a standalone in long cycles (12 weeks or less), or just prior to an anabolic steroid cycle (bridge into the cycle).  Ostarine on cycle is stupid.

-Travis DeGraff

Side Note – Ostarine is actually a drug in development.  The company currently studying Ostarine (enobosarm) GTx Inc. has just finished Phase III clinical trials [4].  This means that there are yet to be published studies (2 to be exact) on thousands of participants.  According to the early news they went well, which means Ostarine could be classified as a drug at any time.  It also means that it will no longer be sold as a supplement (legally that is), so if you are considering trying it, it may not be best to wait.  Learn more about Ostarine here.

6 thoughts on “Ostarine On Cycle is Stupid

  1. OldliftR says:

    Can you site the graph (where the numbers for hormone levels dropping came from) used in this article?

    • DeGraff says:

      It’s referenced in the brackets surrounding the 1 I believe:

      The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial.

      AuthorsDalton JT, et al. Show all Journal
      J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):153-161. Epub 2011 Aug 2.

      Affiliation
      Abstract
      BACKGROUND: Cachexia, also known as muscle wasting, is a complex metabolic condition characterized by loss of skeletal muscle and a decline in physical function. Muscle wasting is associated with cancer, sarcopenia, chronic obstructive pulmonary disease, end-stage renal disease, and other chronic conditions and results in significant morbidity and mortality. GTx-024 (enobosarm) is a nonsteroidal selective androgen receptor modulator (SARM) that has tissue-selective anabolic effects in muscle and bone, while sparing other androgenic tissue related to hair growth in women and prostate effects in men. GTx-024 has demonstrated promising pharmacologic effects in preclinical studies and favorable safety and pharmacokinetic profiles in phase I investigation.

      METHODS: A 12-week double-blind, placebo-controlled phase II clinical trial was conducted to evaluate GTx-024 in 120 healthy elderly men (>60 years of age) and postmenopausal women. The primary endpoint was total lean body mass assessed by dual energy X-ray absorptiometry, and secondary endpoints included physical function, body weight, insulin resistance, and safety.

      RESULTS: GTx-024 treatment resulted in dose-dependent increases in total lean body mass that were statistically significant (P < 0.001, 3 mg vs. placebo) and clinically meaningful. There were also significant improvements in physical function (P = 0.013, 3 mg vs. placebo) and insulin resistance (P = 0.013, 3 mg vs. placebo). The incidence of adverse events was similar between treatment groups.

      CONCLUSION: GTx-024 showed a dose-dependent improvement in total lean body mass and physical function and was well tolerated. GTx-024 may be useful in the prevention and/or treatment of muscle wasting associated with cancer and other chronic diseases.

  2. Yoyo noob says:

    So, how much lean muscle gain could on expect off of an 8-10 week cycle of ostarine? Also, should a high end test booster like activate xtreme, be taken as like a pct , or during a cycle, or both?

  3. shaun says:

    thats strange as i did used ostarine on cycle to benefit only form its fat burning properties as i cauldnt find decent anavar on the market where i live.Mission succesful and I see no problem stacking it with testo for more definition than with testo alone.

  4. Thanks for the information on Ostarine SARMS

  5. Dennis says:

    I was thinking about stacking OSTA with the Magnum Thrust test booster. Is this what you are talking about when you say stacking OSTA is stupid? if so, when should I take the Thrust, after the OSTA cycle?

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