Prohormones and Lipids

Perhaps one of the more concerning side effects of oral prohormone use (and some other forms of AAS), are the negative lipid alterations.  If you listened to Episode #4 of the Podcast with the author of Metabolic Alchemy you know that prohormone use can cause a decrease in good cholesterol (HDL), and an increase in bad cholesterol (LDL) and triglycerides.  All three are considered markers of cardiovascular disease (CVD).

Before I go into more detail on panthethine lowering cholesterol, keep in mind there have been no reported cardiovascular related deaths specific to prohormone use.  Unlike caffeine for example, of which a litany of case studies have been written [1].  Still keeping your lipids in check is a healthy way to prohormone cycle.  We cycle prohormones for gains, but at the end of they day both the quality, and quantity (or lifespan) should be important to you, just as it is to me.

Panthethine Lowers Cholesterol

With that in mind, a new study popped up that looks very interesting [2].  Unfortunately I do not yet have access to the full text, but the abstract is quite informative.  In this new study they used all kinds of controls, and apparently strict protocols (as it appears from the panthethine lowers cholesterolabstract), which is important.  Here’s a list that describes the general set up:

  • 32 study participants
  • Randomized
  • Triple blinded
  • Placebo controlled
  • Low to Moderate CVD risk
  • Diet controlled


  • 600 mg’s of panthethine weeks 1 to 8
  • 900 mg’s of panthethine weeks 9 to 16
  • Or placebo supplementation

They found that panthethine decreased total cholesterol vs. placebo at the end of 16 weeks.  They also found a significant decrease in bad cholesterol (LDL-C) at 8 and 16 weeks vs. placebo.  LDL-C actually decreased by 11% at all time points (Weeks 4, 8, 12, and 16), while placebo increased 3% by week 16.    Overall this is an exciting finding, especially because at the end of a prohormone cycle (especially “methyls”) many guys might be considered as low to moderate risk for CVD.  In fact, I cannot count how many times I have seen guys say their physician tried to put them on a statin (cholesterol lowering drug), after a prohormone cycle.

So knowing panthethine lowers cholesterol suggests it may be a good addition to your prohormone cycle, or at the very least a nice addition to post cycle therapy (PCT).  And if you need another reason to supplement panthethine, it has been found to decrease the hangover effects of alcohol if taken before a night out [3].  On top of those reasons, it’s also cheap on amazon.

By Travis DeGraff


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