Another study finds a new amphetamine like analog in a popular preworkout made by former Mr. Olympia Dorian Yates.
If you recall late last year USA Today author Alison Young reported that an amphetamine “like” substance was found in 9 different diet supplements, including iForce Dexaprine XR [Ref. 1]. All of those supplements were labeled with acacia rigidula, which is what some believe is the natural source of these amphetamine analogs. But in June I reported on a paper that specifically tested samples of Dexaprine XR. The authors found that Dexaprine XR contained two different PEA analogs which were referred to as N-alkyl-β-methyl-β-phenylethylamines. Interestingly they also reported that none of the major components of acacia rigidula were found in Dexaprine XR. This inferred that acacia rigidula was not actually an ingredient in Dexaprine, but rather something else that included these PEA analogs.
Fast forward to a paper published on Halloween, which tested NOXPUMP a preworkout made by Dorian Yates under Yates Nutrition [Ref. 2]. NOXPUMP is also labeled with acacia rigidula leaves (Therm RX). They chose to test this supplement because four different WADA tested athletes failed drug tests after they found an amphetamine like substance in their urine.
The designer stimulant is described as being similar to amphetamine amines dimethylamphetamine and phenpromethamine. In the image below it is called N,N-dimethyl-2-phenylpropan-1-amine, or NN-DMPPA for short.
A packet or sachet of Yates NOXPUMP is said to include 15 grams of the combination of all ingredients. In this test (using a 100 mg sample), they found that NN-DMPPA constituted approx. 122 mcg’s/g. So for a 15 grams packet, approximately 1.8 milligrams of NN-DMPPA. Whether or not this constitutes a dose high enough to illicit a stimulant response, I do not know. To my knowledge NN-DMPPA has not specifically been tested in humans (although it’s close cousins like dimethylamphetamine have). It’s worth nothing they also found 18.2 mg/g of β-methylphenethylamine in NOXPUMP as well.
In the end, all of this means very little to those interested in strong stimulants. I say this because there is an ongoing debate about what the acacia rigidula plant truly contains naturally. It seems as though some companies may be including spikes or contaminated acacia rigidula in their products, while others may just have poor quality control, or incomplete testing methods. To date, I’m not aware of any case studies showing detrimental impact with most of these supplements (not including the host of Dexaprine XR issues in Europe). And in some cases these popular products are counterfeited, with little repercussion. If you take anything from this continued battle of what is and what is not in designer stimulants, it is that you should be careful when using them. Escalate the dose up, there is not need to double the recommended dose on your first try. And if you are sensitive to mild stimulants like caffeine, perhaps pass on these elaborate formulations.